Pretreatment with nicorandil can reduce the infarct size, ameliorate micro vascular perfusion and preserve left ventricular systolic function in canine heart model of 3 hours ischemia followed by 2 hours reperfusion. And 24 hours after pretreatment with nicorandil, it can provide significant cardio protective effects on canine myocardium. All these effects can be blocked with glibencamide. http://www.res-medical.com/clinical-medicine/26702
